Previous training: Bénédicte Chazaud’s lab, Claude Bernard University, Lyon, France

The important roles of the niche on stem cell functions have been described across tissues and organisms. In skeletal muscle, muscle stem cells or satellite cells also receive environmental cues to activate, proliferate and differentiate to ensure skeletal muscle homeostasis. However, what signals guide the muscle stem cells to form the niche or comeback to the niche after regenerate the myofibers? The mechanisms regulating niche occupancy by muscle stem cell remain poorly known. My research aims to understand how niche entry is regulated from human muscle stem cells and characterise their behaviour when engrafted into mouse muscle. Understanding muscle stem cell and its niche interactions would allow better manipulation of pluripotent stem cell-derived muscle stem cell, contributing to the development of cell-based therapy for several myopathies.